CHIMERIC ANTIGEN RECEPTORS BASED ON SINGLE-DOMAIN ANTIBODIES AND METHODS OF USE THEREOF

Provided herewith is a chimeric antigen receptor (CAR) comprising a polypeptide comprising: (a) an extracellular antigen binding domain comprising a first single-domain antibody (sdAb) specifically binding to a first antigen and a second sdAb specifically binding to a second antigen, wherein at leas...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	FAN, XIAOHU, ZHUANG, QIUCHUAN, HAO, JIAYING, CHOU, CHUANU, WANG, LIN, WANG, PINGYAN, YANG, LEI
Format:	Patent
Sprache:	eng ; srp
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Provided herewith is a chimeric antigen receptor (CAR) comprising a polypeptide comprising: (a) an extracellular antigen binding domain comprising a first single-domain antibody (sdAb) specifically binding to a first antigen and a second sdAb specifically binding to a second antigen, wherein at least one of the first antigen and the second antigen is BCMA; (b) a transmembrane domain; and (c) an intracellular signaling domain. Further provided herewith is an isolated nucleic acid comprising a nucleic acid sequence encoding the CAR, a vector comprising the isolated nucleic acid, and an engineered immune effector cell comprising the CAR, the isolated nucleic acid, or the vector. Also provided herewith is a pharmaceutical composition comprising the engineered immune effector cell, and the pharmaceutical composition for use in treating cancer.