EGF(A) ANALOGUES WITH FATTY ACID SUBSTITUENTS

The invention relates to compounds derived from the EGF(A) domain of LDL-R, in particular compounds comprising a peptide analogue of the wild-type EGF(A) (LDL-R(293-332)) sequence and at least one substituent comprising at least one fatty acid group. The invention also relates to a pharmaceutical co...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	WIECZOREK, BIRGIT, KODRA, JÁNOS TIBOR, GARIBAY, PATRICK WILLIAM, CHEN, JIANHE, LAU, JESPER F, THØGERSEN, HENNING, RASMUSSEN, SALKA ELBØL, LINDEROTH, LARS
Format:	Patent
Sprache:	eng ; srp
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The invention relates to compounds derived from the EGF(A) domain of LDL-R, in particular compounds comprising a peptide analogue of the wild-type EGF(A) (LDL-R(293-332)) sequence and at least one substituent comprising at least one fatty acid group. The invention also relates to a pharmaceutical composition thereof and use a medicament. The novel EGF(A) compounds of the invention are useful as treatment e.g. in the field of cholesterol lowering, dyslipidaemia and cardiovascular disease.