ARYL ETHERS AND USES THEREOF

ARYL ETHERS AND USES THEREOF

The present disclosure relates to HIF-2a inhibitors and methods of making and using them for treating cancer. Certain compounds were potent in HIF-2a scintillation proximity assay, luciferase assay, and VEGF ELISA assay, and led to tumor size reduction and regression in 786-O xenograft bearing mice...

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Bibliographische Detailangaben
Hauptverfasser: WANG, BIN, SCHLACHTER, STEPHEN, T, XU, RUI, WEHN, PAUL, YANG, HANBIAO, WALLACE, ELI, M, DIXON, DARRYL, DAVID, RIZZI, JAMES, P, JOSEY, JOHN, A, GRINA, JONAS
Format: Patent
Sprache:eng ; srp
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present disclosure relates to HIF-2a inhibitors and methods of making and using them for treating cancer. Certain compounds were potent in HIF-2a scintillation proximity assay, luciferase assay, and VEGF ELISA assay, and led to tumor size reduction and regression in 786-O xenograft bearing mice in vivo.