MACROCYCLIC INHIBITORS OF THE PD-1/PD-L1 AND CD80(B7-1)/PD-L1 PROTEIN/PROTEIN INTERACTIONS

The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.

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Bibliographische Detailangaben
Hauptverfasser:	MAPELLI, CLAUDIO, BOY, KENNETH M, POIRIER, MAUDE A, SANGHVI, NISHITH, MILLER, MICHAEL MATTHEW, SCOLA, PAUL MICHAEL, ALLEN, MARTIN PATRICK, MULL, ERIC, SUN, LI-QIANG, YEUNG, KAP-SUN, ZHU, JULIANG, TENNEY, DANIEL J, REID, PATRICK C, LANGLEY, DAVID R, BOWSHER, MICHAEL S, GILLIS, ERIC P
Format:	Patent
Sprache:	eng ; srp
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES TESTING
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Beschreibung
Zusammenfassung:	The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.