PREPARATION OF A SOLID FORM OF GADOBENATE DIMEGLUMINE

The present invention relates to a process for the preparation of a solid form of the gadobenate dimeglumine compound that essentially comprises obtaining a solution of the said compound in a suitable solvent A and adding, under stirring and appropriate temperature conditions, the said obtained solu...

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Bibliographische Detailangaben
Hauptverfasser:	MAZZON, ROBERTA, FRETTA, ROBERTA, ANELLI, PIER, LUCIO
Format:	Patent
Sprache:	eng ; srp
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention relates to a process for the preparation of a solid form of the gadobenate dimeglumine compound that essentially comprises obtaining a solution of the said compound in a suitable solvent A and adding, under stirring and appropriate temperature conditions, the said obtained solution in a suitable organic solvent B, acting as an appropriate antisolvent and favoring the formation and precipitation of solid particles of the complex compound that can be easily collected by filtration in high yields and in a reliable way.