DIHYDROPYRIDONE P1 AS FACTOR XIA INHIBITORS

DIHYDROPYRIDONE P1 AS FACTOR XIA INHIBITORS

or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising thes...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: FANG, TIANAN, PINTO, DONALD, J.P., PINTO, EWING, WILLIAM, R, SMITH II, LEON, M, CORTE, JAMES, R, PABBISETTY, KUMAR, B, DILGER, ANDREW, K, GILLIGAN, PAUL, J, YANG, WU, WANG, YUFENG
Format: Patent
Sprache:eng ; srp
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.