5-LIPOXYGENASE-ACTIVATING PROTEIN (FLAP) INHIBITORS

Jedinjenje, naznačeno time što je to 3-[3-terc-butilsulfanil-1-[4-(6-etbksi-piridin-3-il)-benzil]-5-(5-metil-piridin-2-ilmetoksi)- 1H-indol-2-il]-2,2-dimetil-propionska kiselina ili njena farmaceutski prihvatljiva so, farmaceutski prihvatljiv N-oksid ili farmaceutski prihvatljiv solvat.Prijava sadrž...

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Hauptverfasser:	PRASIT, PETPIBOON, PEPPI, LI, YIWEI, STOCK, NICHOLAS, SIMON, HADDACH, MUSTAPHA, MORAN, MARK, ZUNIC, JASMINE, ELEANOR, STEARNS, BRIAN, ANDREW, ROPPE, JEFFREY, ROGER, EVANS, JILLIAN, F, HUTCHINSON, JOHN, H, ARRUDA, JEANNIE, M
Format:	Patent
Sprache:	eng ; srp
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:	Jedinjenje, naznačeno time što je to 3-[3-terc-butilsulfanil-1-[4-(6-etbksi-piridin-3-il)-benzil]-5-(5-metil-piridin-2-ilmetoksi)- 1H-indol-2-il]-2,2-dimetil-propionska kiselina ili njena farmaceutski prihvatljiva so, farmaceutski prihvatljiv N-oksid ili farmaceutski prihvatljiv solvat.Prijava sadrži još 28 patentnih zahteva. Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions or diseases.