METHOD FOR PREDICTING THE RESPONSE TO A TREATMENT WITH A HER DIMERIZATION INHIBITOR

METODA ZA PREDVIĐANJE ODGOVORA NA TRETMAN INHIBITORIMA DIMERIZACIJE HER, kod pacijenata koja obuhvata sledeće stupnjeve:a) određivanje, u uzorku biološkog materijala pacijenta, gde je taj uzorak krvni serum, nivoa ekspresije- marker proteina kodiranog marker genom za transformišući faktor rasta alfa...

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Hauptverfasser:	STRAUSS, ANDREAS, ZUGMAIER, GERHARD, MOECKS, JOACHIM
Format:	Patent
Sprache:	eng ; srp
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TESTING VINEGAR WINE
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Zusammenfassung:	METODA ZA PREDVIĐANJE ODGOVORA NA TRETMAN INHIBITORIMA DIMERIZACIJE HER, kod pacijenata koja obuhvata sledeće stupnjeve:a) određivanje, u uzorku biološkog materijala pacijenta, gde je taj uzorak krvni serum, nivoa ekspresije- marker proteina kodiranog marker genom za transformišući faktor rasta alfa ili- kombinacije marker proteina koju kodiraju marker geni, gde se kombinacija marker proteina koju kodiraju marker geni sastoji od marker proteina koje kodiraju- marker gen za transformišući faktor rasta alfa i za HER2,- marker gen za transformišući faktor rasta alfa i marker epidermalnog faktora rasta,- marker gen za amfiregulin i marker transformišućeg faktor rasta alfa- marker gen za transformišući faktor rasta alfa, epidermalni faktor rasta i marker HER2,- marker gen za amfiregulin, za epidermalni faktor rasta i marker transformišućeg faktora rasta alfa,- marker gen za amfiregulin, gen za transformišući faktor rasta alfa i marker HER2,- marker gen za epidermalni faktor rasta, transformišući faktor rasta alfa i marker HER2,- marker gen za amfiregulin, epidermalni faktor rasta, za transformišući faktor rasta alfa i marker HER2,b) za predviđanje odgovora na tretiranje pacijenta inhibitorom dimerizacije HER procenjivanjem rezultata stupnjeva a).Prijava sadrži još 14 patentnih zahteva. The invention is related to a method of predicting the response to a treatment with a HER dimerization inhibitor in a patient comprising the steps of assessing a marker gene or a combination of marker genes selected from the group consisting of an epidermal growth factor, a transforming growth factor alpha and a HER2 marker gene or a combination of marker genes comprising an amphiregulin marker gene and a marker gene selected from an epidermal growth factor, a transforming growth factor alpha and a HER2 marker gene in a biological sample from the patient and predicting the response to the treatment with the HER dimerization inhibitor in the patient by evaluating the results of the first step. Further uses and methods wherein these markers are used are disclosed.