18-METHYL-19-NOR-ANDROST-4-EN-17,17-SPIROETHER(18METHYL-19-NOR-20-SPIROX-4-EN-3-ONE) AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME

18-metil-15β, 16β-metilen-19-nor-20-spiroks-4-en-3-oni opšte formule Inaznačeni time daZ predstavlja atom kiseonika, dva atoma vodonika, grupu =NOR ili =NNHSO2R, pri čemu je R atom vodonika ili alkil grupa pravog ili razgranatog lanca sa 1 do 4 odn. 3 do 4 ugljenikova atoma,R4 predstavlja atom vodonika, atom halogena ili trifluor metil grupu,i R6 i/ili R7 može biti u α ili β položaju i R6 i R7 nezavisno jedno od drugog atom vodonika ili alkil grupa pravog ili razgranatog lanca sa 1 do 4 odn. 3 do 4 ugljenikova atoma ili alkenil grupa pravog ili razgranatog lanca sa 2 do 4 odn. 3 do 4 ugljenikova atoma ili zasićena cikloalkil grupa sa 3 do 5 atoma ugljenika ili zajedno metilen grupa ili dvostruka veza.Prijava sadrži još 12 patentnih zahteva. The present invention describes the novel 18-methyl-19-norandrost-4-ene 17,17-spiro ethers of the general formula I in which Z is an oxygen atom, two hydrogen atoms, a group NOR or NNHSO2R, where R is a hydrogen atom or a straight- or branched-chain alkyl group having 1 to 4 or 3 to 4 carbon atoms, R4 is a hydrogen atom, a halogen atom or a trifluoromethyl group, and R6 and/or R7 may have α or configuration, and R6 and R7 are independently of one another a hydrogen atom or a straight- or branched-chain alkyl group having 1 to 4 or 3 to 4 carbon atoms or a straight- or branched-chain alkenyl group having 2 to 4 or 3 to 4 carbon atoms or a saturated cycloalkyl group having 3 to 5 carbon atoms or together are a methylene group or a double bond. The novel compounds have progestational and antimineralocorticoid activity.