1,4-DIHYDROPYRIDINE-FUSED HETEROCYCLES, PROCESS FOR PREPARING THE SAME, USE AND COMPOSITIONS CONTAINING THEM

Jedinjenje opšte formule (I)gde:X ije NH ili CR7 i* kada X=NH, R2 je:- aril supstituisan supstituentom odabranim od S-R9, NH-R9, (C=O)-NH-R9, (C=O)-NH-CH2-R9, NH-(C=O)-R9, NH-(C=O)-NH-R9, (SO2)-NH-R9ili- heteroaril supstituisna supstituentom odabranim od O-R9, S-R9, NH-R9, (C=O)-NH-R9, (C=O)-NH-CH2-R9, NH-(C=O)-R9, NH-(C=O)-NH-R9, (SO2)-NH-R9* kada X= CR7, R2 je aril ili Heteroaril supstituisan supstituentom odabranim od O-R9 S-R9l NH-R9) (C=O)-NH=R9, (C=O)-NH=CH2-R9, NH-(C=O)-R9, NH-(C=O)=NH-R9, (SO2)-NH-R9;* R9 je odabran od arila i heteroarila po izboru supstituisan supstituentom odabranim od H, F, Cl,. Br, OH, SH, CF3, OCF3, OCH3, SCF3, SCH3, OCHF2, OCH2F, (C1-C6)alkil, O-alil, fenil, i fenil supstituted halogenom;* Y, Y' i Y":(i) svaki nezavisno predstavlja supstituent odabran od CH2, CHR5, CR5R6. C=O, O, S, NH, i NR7; or(ii) together predstavlja supstituent odabran od -CH2-O-(C=O)-, -(CH2)4- i -(CH2)2-lanca;* R7 predstavlja supstituent odabran od: R8, COOR8, COR8, i tONHR8 ;* R5 i R6 svaki nezavisno predstavlja R8;* R8 predstavlja H ili po izboru supstituisan: -alkil, -alkil-alkilen, -alkilen, -heterocikloalkil, - cikloalkil, -aril, -heteroaril, -alkil-heterocikloalkil, -alkil-cikloalkil, - alkil-aril, ili -alkilbeteroaril.Prijava sadrži još 15 patentnih zahteva. 1,4-Dihydropyridine-fused heterocycles, process for preparing the same, use and compositions containing them. The outstanding invention is about substituted dihydropyridine-fused heterocycles useful for the treatment of cancer disease, especially for preventing cancerous cells to divide. These compounds act as inhibitors of Aurora A and/or B kinases.