NEW COMPOUNDS AND THEIR USE IN MEDICINE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEIM

The present invention relates to novel antidiabetic, hypolipidemic, antiobesity and hypocholesterolemic compounds of formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. More particularly, the present invention relates to compounds of the general formula (I) which are predominantly PPAR alpha agonists, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them The present invention also relates to processes for the preparation of novel compounds of formula (I), novel intermediates, processes for their preparation, use of the novel intermediates in the preparation of the above said compounds and their use as antidiabetic, hypolipidemic, antiobesity and hypocholesterolemic compounds. Izloženi pronalazak se odnosi na nova antidijabeticna, hipolipidemicna, antiobezitasna i hipoholesterolemicna jedinjenja formule (I), njihove derivate, analoge, tautomerične oblike, njihove stereoizomere, polimorfe, farmaceutski prihvatljive soli, farmaceutski prihvatljive rastvore i farmaceutski prihvatljive smese koje ih sadrže. Još preciznije, izloženi pronalazak se odnosi na jedinjenja opšte formule (I) koja su pretežno PPAR alfa agonisti, njihove derivate, analoge, tautomericne oblike, njihove stereoizomere, polimorfe, farmaceutski prihvatljive soli, farmaceutski prihvatljive rastvore i farmaceutski prihvatljive smese koje ih sadrže. Izloženi pronalazak se takodje odnosi na postupke za dobijanje novih jedinjenja formule (I), nove intermedijatore, postupke za njihovo dobijanje, upotrebu novih intermedijatora za dobijanje pomenutih jedinjenja i njihovu upotrebu kao antidijabeticna, hipolipidemicna, antiobezitasna i hipoholesterolemična jedinjenja.