INDOLE-2-CARBOXAMIDES AS FACTOR XA INHIBITORS

The present invention relates to compounds of the formula (I), in which R0; R1; R2; R3; R4; R5; R6; R7; Q; V, G and M have the meanings indicated in the claims. The compounds of the formula (I) are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardiovascular disorders like thromboembolic diseases or restenoses. They are reversible inhibitors of the blood clotting enzymes factor Xa (FXa) and/or factor VIIa (FVIIa), and can in general be applied in conditions in which an undesired activity of factor Xa and/or factor VIIa is present or for the cure or prevention of which an inhibition of factor Xa and/or factor VIIa is intended. The invention furthermore relates to processes for the preparation of compounds of the formula (I), their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them. Ovaj pronalazak se odnosi na jedinjenja formule I gde R0, R1, R2, R3, R4, R5, R6, R7, Q, V, G i M imaju značenja naznačena u patentnim zahtevima. Jedinjenja formule (I) su vredna farmakološki aktivna jedinjenja. Ona ispoljavaju jak antitrombotski efekat i pogodna su za, na primer, terapiju i profilaksu kardiovaskularnih poremećaja, kao što su tromboembolijske bolesti ili restenoza. To su reversibilni inhibitori faktora Xa i/ili faktora VIIa enzima za zgrušavanje krvi, a obično se mogu primeniti u stanjima u kojima je prisutna nepoželjna aktivnost faktora Xa i/ili faktora VIIa, ili za lečenje ili prevenciju u kojima se zahteva inhibicija faktora Xa i/ili faktorwa VIIa. Ovaj pronalazak se još odnosi na potupke za dobijanje jedinjenja formule I, na njihovu upotrebu, a naročito kao aktivnih sastojaka u medikamentima ili farmaceutskim preparatima koji ih sadrže.