FORMULATION OF THE MATRIX SYSTEM WITH CURCUMNE

The invention belongs to the field of pharmaceutical products, based on the matrix systems, consisting of thermosensitive hydrogel poly(N-isopropylmethacrylamide-co-N-isopropylacrylamide), p(NIPMAM-NIPAM) in which were incorporated the inclusion complex of curcumin and 2-hydroxypropyl-β - cyclodextrin. The special absorption characteristics of copolymer p(NIPMAM-NIPAM) and the sensitivity to temperature changes due to presence of carbonyl and amino groups, make it a suitable carrier for drug delivery. The advantage of the presence of inclusion complex in production of the drug formulation can be observed as increased solubility and dissolution rate of the complex in comparision to the pure active substance and better bioavailability of curcumin. Formulated matrix system provides a modified release of curcumin at temperature of 37°C and at pH value of 7, 4 like as the pH value in small intestine is. Pronalazak pripada oblasti farmaceutskih proizvoda, na bazi matriks sistema koji sačinjavaju termo-osetljivi hidrogel poli(N-izopropilmetakrilamid-ko-N-izopropilakrilamid), p(NIPMAM-NIPAM) u koji su inkorporisani kurkumin i inkluzioni kompleks kurkumina i 2-hidroksipropil-β-ciklodekstrina. Posebne apsorbujuće karakteristike kopolimera p(NIPMAM -NIPAM) i osetljivost na promenu temperature usled prisustva karbonilnih i amino grupa, omogućavaju da se primeni kao pogodan nosač za isporuku lekova. Prednost prisustva inkluzionog komleksa u izradi lekovite formulacije ogleda se u povećanju rastvorljivosti i brzine rastvaranja kompleksa u odnosu na čistu aktivnu supstancu i boljoj bioraspoloživosti kurkumina. Formulisani matriks sistem omogućava modifikovano oslobađanje kurkumina na temperaturi 37°C i pri pH vrednosti 7, 4 koja odgovara pH vrednosti tankog creva.