PYRAZOLE DERIVATIVES AND THEIR MEDICAL USE

Compounds of formula (1), or a pharmaceutically acceptable derivative thereof, wherein R1 and R3 independently represent H, C1-6alkyl, C3-8cycloalkyl, or halogen; R2 represents C1-6alkyl, CF3 or aryl; a represents 1 or 2; R4, R5, R7 and R8 independently represent H, C1-6alkyl, C1-6alkyloxy, CN or halogen, or R4 and R5, or R7 and R8, together with the ring to which they are attached form an aryl or heterocyclic fused ring system; X represents C or N; Y represents CH2 or O; R6 represents H, CN or halo, but when X represents N then R6 represents H; may be useful for treating endometriosis, uterine fibroids (leiomyomata), menorrhagia, adenomyosis, primary and secondary dysmenorrhoea (including symptoms of dyspareunia, dyschexia and chronic pelvic pain), or chronic pelvic pain syndrome. Jedinjenja formule (1), ili njihovi farmaceutski prihvatljivi derivati, gde R1 i R3 nezavisno predstavljaju H, C1-6alkil, C3-8cikloalkil, ili halogen; R2 predstavlja C1-6alkil, CF3 ili aril; a predstavlja 1 ili 2; R4, R5, R7 i R8 predstavljaju nezavisno H, C1-6alkil, C1-6alkiloksi, CN ili halogen, ili R4i R5, ili R7 i R8, zajedno sa prstenom za koji su vezani čine aril ili heterociklični sistem kondenzovanih prstenova; X predstavlja C ili N; Y predstavlja CH2 ili O; R6 predstavlja H, CN ili halo, ali kada X predstavlja N tada R6 predstavlja H; mogu biti korisna za tretiranje endometrioze, fibroida materice (leiomioma), menoragije, adenomioze, primarne i sekundarne dismenoreje (uključujući simptome dispareunije, disheksije i hroničnog pelvičnog bola), ili sindroma hroničnog pelvičnog bola.