NOVEL COMPOSITIONS FOR TOPICAL DELIVERY

Pharmaceutical composition for topical administration comprising of at least one active ingredient, its salts, esters, hydrates or derivatives; a gelator system consisting of a fiend of surfactants, a solvent system comprising at least one oily component; an aqueous phase; optionally containing one or more stabilizing agent; and other pharmaceutically acceptable excipients; and process for preparing such compositions are provided. Also provided is a method for the management/treatment of fungal, bacterial or microbial infections, inflammations, autoimmune conditions, or hormonal disorders which comprises administering a pharmaceutically effective amount of such pharmaceutical composition to a subject in need of such treatment. The compositions of the present invention are non-greasy and easily water washable, and provides an enhanced localization of hydrophobic and/or amphiphilic active ingredients on the skin. Obezbeđen je farmaceutski sastav za lokalnu primenu koji sadrži bar jedan aktivni sastojak, njegove soli, estre, hidrate ili derivate; gelatorni sistem koji se sastoji od smeše surfaktanata, rastvaračkog sistema koji sadrži bar jednu uljnu komponentu; vodenu fazu; koji opciono sadrži jedan ili više stabilizatora; i druge farmaceutski prihvatljive inertne punioce; i postupak za dobijanje takvih sastava. Takođe je obezbeden metod za lečenje/tretman gljivičnih, bakterijskih ili mikrobnih infekcija, upala, autoimunih oboljenja, ili hormonalnih poremećaja koji obuhvata davanje farmaceutski efektivne količine takvog farmaceutskog sastava pacijentu prema potrebi. Sastavi ovog pronalaska su nemasni i lako se ispiraju vodom, i omogućuju povećanu lokalizaciju hidrofobnih i/ili amfifilnih aktivnih sastojaka na koži.