ANTIPARASITIC TERPENE ALKALOIDS

The present invention relates to novel terpene alkaloids and their use as antiparasitic agents. The present invention also relates to an antiparasitic agent which comprises a terpene alkaloid compound of this invention as an effective ingredient in an antiparasitic formulation. More particularly, th...

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Bibliographische Detailangaben
Hauptverfasser:	WIEDENAU PAUL HEINRICH, RUDGE ANDREW JOHN, CRITCHER DOUGLAS JAMES, WALSHE NIGEL DEREK, CHUBB NATHAN ANTHONY LOGAN, LUNN GRAHAM, ESHELBY JAMES JOHN, WILLIAMS DAVID HOWARD
Format:	Patent
Sprache:	eng ; srp
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES CHEMISTRY FISHING FORESTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HUNTING HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TRAPPING
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Beschreibung
Zusammenfassung:	The present invention relates to novel terpene alkaloids and their use as antiparasitic agents. The present invention also relates to an antiparasitic agent which comprises a terpene alkaloid compound of this invention as an effective ingredient in an antiparasitic formulation. More particularly, the present invention relates to derivatives of the terpene alkaloid (1S,2R,4aS,5R,8R,8aR)-2-(acetyloxy)- 8a-hydroxy-3,8-dimethyl-5-(1 -methylethenyl)-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl (2S,3aR,9bR)-6 -chloro-9b-hydroxy-5- methyl-1,2,3,3a,5,9b-hexahydropyrrolo[2,3-c][2,1]benzoxazine-2-carboxylate. Pharmaceutical compositions comprising the same are also disclosed. Ovaj pronalazak se odnosi na nove terpenske alkaloide i njihovu upotrebu kao antiparazitskih agenasa. Ovaj pronalazak se takodje odnosi na antiparazitski agens koji sadrži terpensko alkaloidno jedinjenje iz ovog pronalaska kao efikasni sastojak u antiparazitskoj formulaciji. Odredjenije, ovaj pronalazak se odnosi na derivate terpenskog alkaloida (1S,2R,4aS,5R,8R,8aR)-2-(acetiloksi)-8a-hidroksi3,8-dimetil-5-(1-metiletenil)-1,2,4a,5,6,7,8,8a-oktahidronaftalin-1-il (2S,4aR,9bR)-6-hloro-9b-hidroksi-5-metil-1,2,3,3a,5,9b-heksihidropirolo [2,3-c][2,1]benzoksazin-2-karboksilata. Opisani su takodje farmaceutski preparati koji sadrže iste.