PREPARATION OF QUINAPRIL HYDROCHLORIDE

PREPARATION OF QUINAPRIL HYDROCHLORIDE

Methods and materials for preparing quinapril, its pharmaceutically acceptable salts, including quinapril hydrochloride, are disclosed. The method includes reacting (2S,4S)-2-(4-methyl-2,5-dioxo-oxazolidin-3-yl)-4-phenyl-butyric acid ethyl ester with (3S)- 1,2,3,4-tetrahydro-isoquinoline-3-carboxyli...

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Bibliographische Detailangaben
1. Verfasser: JENNINGS SANDRA MARIE
Format: Patent
Sprache:eng ; srp
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:Methods and materials for preparing quinapril, its pharmaceutically acceptable salts, including quinapril hydrochloride, are disclosed. The method includes reacting (2S,4S)-2-(4-methyl-2,5-dioxo-oxazolidin-3-yl)-4-phenyl-butyric acid ethyl ester with (3S)- 1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid tert-butyl ester toyield quinapril tert-butyl ester, which is subsequently reactedwith an acid to yield quinapril or an acid addition salt of quinapril. Otkriveni su postupci i materijali za izradu kvinaprila, njegovih armaceutski prihvatljivih soli, uključujući kvinapril hidrohlorid. Postupak obuhvata rekaciju etil estra (2S, 4S)-2-(4-metil-2,5-diokso-oksazolidin-3-il)-4-fenilbutiratne kiseline sa terc-butil estrom (3S)-1,2,3,4-tetrahidro-izokvinolin-3-karboksilatne kiseline da se dobije kvinapril terc-butil estar koji zatim reaguje sa nekom kiselinom da se dobije kvinapril ili neka so kvinaprila nastala dodatkom kiseline.