N-(1-BENZYL-2-OXO-2-(1- PIPERAZINYL)ETHYL)-1- PIPERIDINCARBOXA MID-DERIVATIVES AND RELATED COMPOUNDS USE AS CGRP- ANTAGONISTS FOR TREATING A HEADACHE

The invention relates to carboxylic acids and esters of a general formula (I), wherein Ar, R, R1, X1, X3, X4, Y and Y1 have a definition given in a claim 1. Said invention also relates to tautomers, the enantiomers, mixtures and salts thereof, in particular to physiologically compatible salts containing organic or inorganic acids or bases, drugs containing said compounds using them as CGRT antagonists for treating a headache and to method for the production and use thereof for producing and cleaning antibodies and as labelled compounds for RIA and ELISA biological dosages and, finally as auxiliary diagnostics or analytics for neutrotransmitters. Predmetni pronalazak se odnosi na karboksilne kiseline i estre opšte formule pri čemu su Ar, R, R1, X1, X3, X4, Y i Y1 definisani kao u zahtevu 1, na njihove tautomere, dijastereomere, enantiomere, njihove smeše i njihove soli, a posebno na njihove fiziološki prihvatljive soli sa neorganskim ili organskim kiselinama ili bazama, na farmaceutske kompozicije koje sadrže ova jedinjenja, na njihovu primenu, kao CGRT antagonista za lečenje glavogolja kao i na postupke za njihovo pripremanje, te na njihovu primenu za dobijanje i prečišćavanje antitela, i kao markiranih jedinjenja u RIA i ELISA testovima, kao i u dijagnostičke ili analitičke svrhe u istraživanjima neurotransmitera.