MAGNETIC NANOSTRUCTURES BASED ON NEUROTENSIN-PEPTIDE-FUNCTIONALIZED POLYMER, LABELED WITH RADIOISOTOPE 64CU FOR DIAGNOSTIC IN ONCOLOGICAL PATHOLOGY

The invention relates to a process for preparing magnetic nanostructures based on poly(benzofuran-co-arylacetic acid) functionalized with peptides and labeled with the radioisotope 64Cu, to be used in oncology, for positron emission tomography (PET) imaging technique. According to the invention, the...

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Hauptverfasser: NEAGOE IONELA VICTORIA, NAN ALEXANDRINA EMILIA, MANDA GINA, DUŞMAN RAMONA-DANIELA, LEONTE RADU-ANTON, TURCU PAULA RODICA, NICULAE DANA, CHILUG ELENA-LIVIA
Format: Patent
Sprache:eng ; rum
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Zusammenfassung:The invention relates to a process for preparing magnetic nanostructures based on poly(benzofuran-co-arylacetic acid) functionalized with peptides and labeled with the radioisotope 64Cu, to be used in oncology, for positron emission tomography (PET) imaging technique. According to the invention, the process consists of the following reaction steps: I. opening the lactonic cycle present in the poly(benzofuran-co-arylacetic acid) structure by the free amino groups of the neurotensin peptide conjugated with the chelating agent DOTA (1,4,7, 10-tetraazacyclododecane-1,4,7,10-tetraacetic acid), II. radioisotope 64 chelation by DOTA and III. absorption of the polymer functionalized with the peptide and labeled with the radioisotope 64Cu on the surface of the magnetic nanoparticles, resulting in radiopharmaceutical nanostructures for PET molecular imaging in solid tumours. Invenţia se referă la un procedeu de obţinere a unor nanostructuri magnetice pe bază de poli(benzofuran-co-acid arilacetic) funcţionalizat cu peptide şi marcate cu radioizotopul 64Cu utilizate în oncologie, pentru tehnica imagistică cu tomografie prin emisie de pozitroni (PET). Procedeul, conform invenţiei, constă în etapele de reacţie: (I) deschiderea ciclului lactonic prezent în structura poli(benzofuran-co-acid arilacetic) de către grupările amino libere ale peptidei neurotensină conjugată cu agentul chelator DOTA (acid 1,4,7,10-tetraazaciclododecan-1,4,7,10-tetraacetic), (II) chelatizarea radioizotopului 64 de către DOTA şi (III) absorbţia polimerului funcţionalizat cu peptida şi marcat cu radioizotopul 64Cu pe suprafaţa nanoparticulelor magnetice, rezultând nanostructuri radiofarmaceutice pentru imagistica moleculară PET în tumorile solide.