BIOCOMPOSITE BASED ON TYPE I COLLAGEN AND ALOE VERA, COMPLEXED WITH SILVER NANOPARTICLES OBTAINED BY GREEN SYNTHESIS FROM AQUEOUS CINNAMON SOLUTION, WITH REGENERATIVE EFFECT ON HUMAN SKIN FIBROBLASTS

BIOCOMPOSITE BASED ON TYPE I COLLAGEN AND ALOE VERA, COMPLEXED WITH SILVER NANOPARTICLES OBTAINED BY GREEN SYNTHESIS FROM AQUEOUS CINNAMON SOLUTION, WITH REGENERATIVE EFFECT ON HUMAN SKIN FIBROBLASTS

The invention relates to a biocomposite with regenerative effect on human skin fibroblasts. According to the invention, the biocomposite is made of silver nanoparticles obtained by green synthesis in cinnamon aqueous extract (NpAg-Sco) combined with type I collagen extracted from fish tails (Hypopht...

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Bibliographische Detailangaben
Hauptverfasser: AVRAM MARIOARA, STAN DIANA, CODRICI ELENA, DUDĂU MARIA, POPESCU IONELA DANIELA, MATEESCU LORENA-ANDREEA, PREDA PETRUŢA, ENCIU ANA-MARIA, TANASE CRISTIANA, ALBULESCU LUCIAN, CODOREAN ELEONORA, ALBULESCU RADU NICOLAE AUREL
Format: Patent
Sprache:eng ; rum
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:The invention relates to a biocomposite with regenerative effect on human skin fibroblasts. According to the invention, the biocomposite is made of silver nanoparticles obtained by green synthesis in cinnamon aqueous extract (NpAg-Sco) combined with type I collagen extracted from fish tails (Hypophthalmichthys molitrix), sodium alginate and aloe vera gel, resulting in a transparent gel which is soluble in aqueous media, with cell proliferation stimulating effect at a concentration ranging between 1...100 mg/ml. Invenţia se referă la un biocompozit cu efect regenerativ pe fibroblaste umane din piele. Biocompozitul, conform invenţiei, este obţinut din nanoparticule de argint obţinute prin sinteza verde în extract apos de scorţişoară (NpAg-Sco), combinate cu colagen tip I extras din cozi de peşte (Hypophthalmichthys molitrix), alginat de sodiu şi gel de aloe vera, rezultând un gel transparent, solubil în medii apoase, cu efect de stimulare a proliferării celulare la o concentraţie cuprinsă între 1...100 mg/ml.