O-ARYL-CARBAMOYL-OXIMINO-DIBENZ[B, E]OXEPINS, PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AND USE THEREOF
The invention relates to O-aryl-carbamoyl-dibenz[b,e]oxepin compounds and to a process for preparing the same, to be used in antimicrobial pharmaceutical compositions. According to the invention, the compounds have the general formula (I). The claimed process consists in refluxing 11-hydroximino-6,1...
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| creator | DRĂGHICI CONSTANTIN NUŢĂ DIANA CAMELIA DINU-PÎRVU CRISTINA ELENA MISSIR ALEXANDRU VASILE LIMBAN CARMEN MARINECI DANA CRISTINA CĂPROIU MIRON TEODOR VLAD ILINCA MARGARETA DUMITRAŞCU FLOREA CHIFIRIUC MARIANA CARMEN ŞTEFĂNESCU EMIL MĂRUŢESCU LUMINIŢA CHIRIŢĂ CORNEL AVRAM SPERANŢA |
| description | The invention relates to O-aryl-carbamoyl-dibenz[b,e]oxepin compounds and to a process for preparing the same, to be used in antimicrobial pharmaceutical compositions. According to the invention, the compounds have the general formula (I). The claimed process consists in refluxing 11-hydroximino-6,11-dihydro-dibenz[b,e]oxepin (VIIa), 2-methyl-11-hydroximino-6,11-dihydro-dibenz[b,e]oxepin (VIIb) or 2-ethyl-11-hydroximino-6,11-dihydro-dibenz[b,e]oxepin (VIIc), with arylisocyanates, in anhydrous tetrahydrofuran reaction medium, to result in dibenz[b,e]oxepin derivatives of low toxicity and high antimicrobial efficiency, both on reference microbial strains and on isolated strains with phenotypes of multi-resistance to known antimicrobial agents. |
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According to the invention, the compounds have the general formula (I). The claimed process consists in refluxing 11-hydroximino-6,11-dihydro-dibenz[b,e]oxepin (VIIa), 2-methyl-11-hydroximino-6,11-dihydro-dibenz[b,e]oxepin (VIIb) or 2-ethyl-11-hydroximino-6,11-dihydro-dibenz[b,e]oxepin (VIIc), with arylisocyanates, in anhydrous tetrahydrofuran reaction medium, to result in dibenz[b,e]oxepin derivatives of low toxicity and high antimicrobial efficiency, both on reference microbial strains and on isolated strains with phenotypes of multi-resistance to known antimicrobial agents.</description><language>eng ; rum</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240228&DB=EPODOC&CC=RO&NR=133659B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,778,883,25547,76298</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240228&DB=EPODOC&CC=RO&NR=133659B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>DRĂGHICI CONSTANTIN</creatorcontrib><creatorcontrib>NUŢĂ DIANA CAMELIA</creatorcontrib><creatorcontrib>DINU-PÎRVU CRISTINA ELENA</creatorcontrib><creatorcontrib>MISSIR ALEXANDRU VASILE</creatorcontrib><creatorcontrib>LIMBAN CARMEN</creatorcontrib><creatorcontrib>MARINECI DANA CRISTINA</creatorcontrib><creatorcontrib>CĂPROIU MIRON TEODOR</creatorcontrib><creatorcontrib>VLAD ILINCA MARGARETA</creatorcontrib><creatorcontrib>DUMITRAŞCU FLOREA</creatorcontrib><creatorcontrib>CHIFIRIUC MARIANA CARMEN</creatorcontrib><creatorcontrib>ŞTEFĂNESCU EMIL</creatorcontrib><creatorcontrib>MĂRUŢESCU LUMINIŢA</creatorcontrib><creatorcontrib>CHIRIŢĂ CORNEL</creatorcontrib><creatorcontrib>AVRAM SPERANŢA</creatorcontrib><title>O-ARYL-CARBAMOYL-OXIMINO-DIBENZ[B, E]OXEPINS, PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AND USE THEREOF</title><description>The invention relates to O-aryl-carbamoyl-dibenz[b,e]oxepin compounds and to a process for preparing the same, to be used in antimicrobial pharmaceutical compositions. According to the invention, the compounds have the general formula (I). 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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | O-ARYL-CARBAMOYL-OXIMINO-DIBENZ[B, E]OXEPINS, PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AND USE THEREOF |
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