O-ARYL-CARBAMOYL-OXIMINO-DIBENZ[B, E]OXEPINS, PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AND USE THEREOF

The invention relates to O-aryl-carbamoyl-dibenz[b,e]oxepin compounds and to a process for preparing the same, to be used in antimicrobial pharmaceutical compositions. According to the invention, the compounds have the general formula (I). The claimed process consists in refluxing 11-hydroximino-6,1...

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Hauptverfasser:	DRĂGHICI CONSTANTIN, NUŢĂ DIANA CAMELIA, DINU-PÎRVU CRISTINA ELENA, MISSIR ALEXANDRU VASILE, LIMBAN CARMEN, MARINECI DANA CRISTINA, CĂPROIU MIRON TEODOR, VLAD ILINCA MARGARETA, DUMITRAŞCU FLOREA, CHIFIRIUC MARIANA CARMEN, ŞTEFĂNESCU EMIL, MĂRUŢESCU LUMINIŢA, CHIRIŢĂ CORNEL, AVRAM SPERANŢA
Format:	Patent
Sprache:	eng ; rum
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The invention relates to O-aryl-carbamoyl-dibenz[b,e]oxepin compounds and to a process for preparing the same, to be used in antimicrobial pharmaceutical compositions. According to the invention, the compounds have the general formula (I). The claimed process consists in refluxing 11-hydroximino-6,11-dihydro-dibenz[b,e]oxepin (VIIa), 2-methyl-11-hydroximino-6,11-dihydro-dibenz[b,e]oxepin (VIIb) or 2-ethyl-11-hydroximino-6,11-dihydro-dibenz[b,e]oxepin (VIIc), with arylisocyanates, in anhydrous tetrahydrofuran reaction medium, to result in dibenz[b,e]oxepin derivatives of low toxicity and high antimicrobial efficiency, both on reference microbial strains and on isolated strains with phenotypes of multi-resistance to known antimicrobial agents.