STABLE PHARMACEUTICAL COMPOSITION WITH AMORPHOUS ROSUVASTATIN CALCIUM

The invention relates to a pharmaceutical composition as tablets for the treatment of hyperlipoproteinemia, hypercholesterolemia and atherosclerosis. According to the invention, the composition comprises amorphous rosuvastatin calcium stabilized with calcium carbonate admixed in a mass ratio of 0.5....

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Bibliographische Detailangaben
Hauptverfasser:	SARAFINCEANU NICOLETA, TELISCA AMALIA-DIANA, MOISUC LACRAMIOARA STEFANIA, MACOVEI LENUTA, BOITA TUDOR, POTUR ROXANA-GEORGIANA
Format:	Patent
Sprache:	eng ; rum
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	The invention relates to a pharmaceutical composition as tablets for the treatment of hyperlipoproteinemia, hypercholesterolemia and atherosclerosis. According to the invention, the composition comprises amorphous rosuvastatin calcium stabilized with calcium carbonate admixed in a mass ratio of 0.5...2:1 and other excipients, as follows: 30...60% lactose monohydrate, 15...35% micro crystalline cellulose, 1...5% crospovidone, 0.25...5% magnesium stearate. Invenţia se referă la o compoziţie farmaceutică sub formă de comprimate, pentru tratamentul hiperlipoproteinemiei, hipercolesterolemiei şi aterosclerozei. Compoziţia conform invenţiei este constituită din rosuvastatină calcică amorfă, stabilizată cu ajutorul carbonatului de calciu adăugat într-un raport masic de 0,5...2:1, şi alţi excipienţi după cum urmează: 30...60% lactoză monohidrat, 15...35% celuloză microcristalină, 1...5% crospovidonă, 0,25...5% stearat de magneziu.