USE OF RISPERIDONE N-OXIDE AS A PRODRUG IN ORAL, PARENTERAL, RECTAL OR TRANSDERMAL TREATMENT WITH RISPERIDONE

USE OF RISPERIDONE N-OXIDE AS A PRODRUG IN ORAL, PARENTERAL, RECTAL OR TRANSDERMAL TREATMENT WITH RISPERIDONE

The invention relates to the use of risperidone N-oxide as a prodrug in antipsychotic treatment. The use of N-oxide type as a prodrug generates a slow conversion to the active entity, risperidone, simultaneously with an increased time of in-vivo remanence, with constant exposure at the central level...

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Bibliographische Detailangaben
Hauptverfasser: DR GHICI CONSTANTIN, R DULESCU FLAVIAN TEFAN, MIRON DALIA SIMONA, VOICU VICTOR
Format: Patent
Sprache:eng ; rum
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:The invention relates to the use of risperidone N-oxide as a prodrug in antipsychotic treatment. The use of N-oxide type as a prodrug generates a slow conversion to the active entity, risperidone, simultaneously with an increased time of in-vivo remanence, with constant exposure at the central level and reduction of inter-individual variability generated by the genetic polymorphism of the metabolizing enzyme. Invenţia se referă la utilizarea N-oxidului risperidonei ca promedicament în tratamentul antipsihotic. Utilizarea de tip N-oxid ca promedicament generează o conversie lentă la entitatea activă, risperidonă, simultan cu un timp de remanenţăcrescut, cu expunere constantă la nivel central şi reducerea variabilităţii interindividuale, generată de polimorfismul genetic al enzimei de metabolizare.