PROCESS FOR PREPARING DERIVATIVES OF 7-AMINO-DELTA3-DEACETOXYCEPHALOSPORANIC ACID
The invention relates to a process for synthesis of some derivatives of the 7-amino-delta3-deacetoxycephalosporanic acid, which are obtained by the cycle extension of the appropriate sulphoxides, silyl-protected by BSU quantitative esterification, in toluen, in a heterogenous three-phase system, in...
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| Format: | Patent |
| Sprache: | eng ; rum |
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| Zusammenfassung: | The invention relates to a process for synthesis of some derivatives of the 7-amino-delta3-deacetoxycephalosporanic acid, which are obtained by the cycle extension of the appropriate sulphoxides, silyl-protected by BSU quantitative esterification, in toluen, in a heterogenous three-phase system, in the presence of the inter-phase transfer catalysts of the type of the ammonium quaternary salts or the crown ethers.
Invenţia se referă la un procedeu de sinteză a unor derivaţi ai acidului 7-amino-delta3-dezacetoxicefalosporanic, ce se obţin prin extinderea de ciclu a sulfoxizilor corespunzători, silil-protejaţi prin esterificare cantitativă cu BSU, în toluen, în sistem trifazic eterogen, în prezenţa catalizatorilor de transfer interfazic, de tipul sărurilor cuaternare de amoniu sau eterilor coroană. ŕ |
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