PROCESS FOR PREPARING (±)-CIS, TRANS-2-(DIMETHYLAMINO)-METHYL-1-(M-METHOXYPHENYL)CYCLOHEXANE-1-OL HYDROCHLORIDE

PROCESS FOR PREPARING (±)-CIS, TRANS-2-(DIMETHYLAMINO)-METHYL-1-(M-METHOXYPHENYL)CYCLOHEXANE-1-OL HYDROCHLORIDE

The invention relates to a process for preparing the (±)cis, trans-2-(dimethylamino)-methyl-1-(m-methoxyphenyl)-cyclohexane-1-ol hydrochloride, consisting in neutralizing the corresponding base with a solution of chlorine hydride concentrated in n-propyl carbinol, with further azeotropic removal of...

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Bibliographische Detailangaben
Hauptverfasser: GUŢĂ RODICA, ILIE CORINA, RĂDUCANU AURELIA, TUDOR SIMONA, ROGOZEA ION, ANDREESCU DOINA
Format: Patent
Sprache:eng ; rum
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The invention relates to a process for preparing the (±)cis, trans-2-(dimethylamino)-methyl-1-(m-methoxyphenyl)-cyclohexane-1-ol hydrochloride, consisting in neutralizing the corresponding base with a solution of chlorine hydride concentrated in n-propyl carbinol, with further azeotropic removal of water, the excess of n-propyl carbinol and chlorine hydride, the resulting product being then isolated by precipitation from anhydrous solvents. Prezenta invenţie se referă la un procedeu de obţinere a clorhidratului de (±)-cis, trans-2-(dimetilamino)-metil-1-(m-metoxifenil)-ciclohexan-1-ol, care constă în aceea că se neutralizează baza corespunzătoare cu o soluţie de acid clorhidric concentrat în alcool n-butilic, după care se îndepărtează azeotropic apa, excesul de alcool n-butilic şi de acid clorhidric, iar produsul se izolează prin precipitare din solvenţi anhidri.