PROCESS FOR PREPARING (E)-N-METHYL-N-(1-NAPHTHYLMETHYL)-3-PHENYL-2-PROPENE-1-AMINE HYDROCHLORIDE

PROCESS FOR PREPARING (E)-N-METHYL-N-(1-NAPHTHYLMETHYL)-3-PHENYL-2-PROPENE-1-AMINE HYDROCHLORIDE

The invention relates to a process for preparing (E)-N-methyl-N-(1-naphthylmethyl)-3-phenyl-2-propene-1-amine hydrochloride of the formula (I): by reacting the (E)-N-methyl-3-phenyl-2-propene-1-amine hydrochloride of the formula (II): with alpha-chloromethyl-naphtalene in an inert organic solvent, i...

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Bibliographische Detailangaben
Hauptverfasser: BÂZDOACĂ CRISTINA MIRELA, DRAGOŞ MARIANA, BURCĂ DUMITRU SENCA, TUDOR DANIELA, FILIP GEORGETA, RADU ROMANA, FUNIERU GABRIELA, DRĂGOLICI AURORA
Format: Patent
Sprache:eng ; rum
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:The invention relates to a process for preparing (E)-N-methyl-N-(1-naphthylmethyl)-3-phenyl-2-propene-1-amine hydrochloride of the formula (I): by reacting the (E)-N-methyl-3-phenyl-2-propene-1-amine hydrochloride of the formula (II): with alpha-chloromethyl-naphtalene in an inert organic solvent, in the presence of an inorganic base, at the environment temperature. The resulting product is isolated as a salt, with chlorine hydride, by crystallization from various solvents. Invenţia se referă la un procedeu pentru obţinerea clorhidratului de (E)-N-metil-N-(1-naftilmetil)-3-fenil-2-propen-1-amină cu formula (I): prin reacţia dintre clorhidratul de (E)-N-metil-3-fenil-2-propen-1-amină cu formula (II): şi alfa-clormetilnaftalina într-un solvent organic inert, în prezenţa unei baze anorganice, la temperatura camerei. Produsul se izolează, sub formă de sare, cu acid clorhidric, prin cristalizare din diferiţi solvenţi.