PROCESS FOR THE ALPHA/BETA RATIO INCREASING IN THE ASPARTAMIC COUPLING REACTION

PROCESS FOR THE ALPHA/BETA RATIO INCREASING IN THE ASPARTAMIC COUPLING REACTION

An improved coupling step of an alpha -APM manufacturing process is disclosed. The solvents in the coupling step are adjusted in one of two ways to improve the alpha - to beta - isomer ratio of the product of the coupling step, alpha , beta protected L-aspartyl-L-phenylalanine or lower alkyl ester t...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
1. Verfasser: GELMAN YEFIM
Format: Patent
Sprache:eng ; rum
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:An improved coupling step of an alpha -APM manufacturing process is disclosed. The solvents in the coupling step are adjusted in one of two ways to improve the alpha - to beta - isomer ratio of the product of the coupling step, alpha , beta protected L-aspartyl-L-phenylalanine or lower alkyl ester thereof. In one manner, the solvent may comprise an increased concentration of a carboxylic acid such as acetic acid alone. In the other manner, one or more additional solvents along with a carboxylic acid such as acetic acid in conventionally known concentrations are used.