PROCESSO PARA AUMENTAR A PROPORCAO DO ISOMERO ALFA PARA O ISOMERO BETA NUMA REACCAO DE PREPARCAO DO ESTER DE 1-METILO DE N-L-ALFA-ASPARTIL-L-FENILANINA (ASPARTAME)

PROCESSO PARA AUMENTAR A PROPORCAO DO ISOMERO ALFA PARA O ISOMERO BETA NUMA REACCAO DE PREPARCAO DO ESTER DE 1-METILO DE N-L-ALFA-ASPARTIL-L-FENILANINA (ASPARTAME)

An improved coupling step of an alpha -APM manufacturing process is disclosed. The solvents in the coupling step are adjusted in one of two ways to improve the alpha - to beta - isomer ratio of the product of the coupling step, alpha , beta protected L-aspartyl-L-phenylalanine or lower alkyl ester t...

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Bibliographische Detailangaben
1. Verfasser: YEFIM GELMAN
Format: Patent
Sprache:por
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Zusammenfassung:An improved coupling step of an alpha -APM manufacturing process is disclosed. The solvents in the coupling step are adjusted in one of two ways to improve the alpha - to beta - isomer ratio of the product of the coupling step, alpha , beta protected L-aspartyl-L-phenylalanine or lower alkyl ester thereof. In one manner, the solvent may comprise an increased concentration of a carboxylic acid such as acetic acid alone. In the other manner, one or more additional solvents along with a carboxylic acid such as acetic acid in conventionally known concentrations are used.