PROCESSO PARA INFLUENCIAR A PRODUCAO DE ANTIBIOTICOS DE BETA-LACTAMA E PARA O ISOLAMENTO DE GRANDES QUANTIDADES DE SINTETASE DE ACV

Novel methods and compositions are provided for the enhanced production of fermentable or known and new beta -lactam antibiotics. The process is exemplified by the production of penicillin. In addition, the P.chrysogenum and A.chrysogenum delta -(L- alpha -aminoadipyl)-L-cysteinyl-D-valine synthetas...

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Hauptverfasser: HANS VON DOEHREN, ANNEMARIE EVELINE VEENSTRA, EDUARDO MONTENEGRO PRIETO, BRUNO DIEZ GARCIA, HARRIET PALISSA, JOSE LUIZ BARREDO, HENK VAN LIEMPT, JUAN FRANCISCO MARTIN, SANTIAGO GUTTIERREZ
Format: Patent
Sprache:por
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Zusammenfassung:Novel methods and compositions are provided for the enhanced production of fermentable or known and new beta -lactam antibiotics. The process is exemplified by the production of penicillin. In addition, the P.chrysogenum and A.chrysogenum delta -(L- alpha -aminoadipyl)-L-cysteinyl-D-valine synthetase genes have been isolated and sequenced. Also methods are provided for the production of delta -(L- alpha -aminoadipyl)-L-cysteinyl-D-valine synthetase using recombined DNA techniques.