CORANTES FUNCIONAIS DELTA1,6 BICICLO¬4.4.0| PARA INTENSIFICACAO DO CONTRASTE EM IMAGIOLOGIA OPTICA

This invention provides functional dyes of the general formula: 1 wherein R1, R2, and R5 may be the same or different and are selected from the group consisting of hydrogen, C1-C10 alkyl, C1-C10 alkoxyl, hydroxyl, C1-C10 hydroxyalkyl, C1-C10 alkoxyalkyl, C1-C10 aryl, carboxyl, C1-C10 carboxylalkyl, halogen, nitro, C1-C10 alkoxycarbonyl, mercapto, C1-C10 mercaptoalkyl, C1-C10 alkylthio, sulfonate, and -(CH2)m-N(R6)(R7) wherein R6 and R7 are independently hydrogen or C1-C10 alkyl, C1-C10 acyl, and R6 and R7 are capable of forming 5, 6, or 7 membered rings which may optionally be substituted with -O-, -NR8, or -S-; R3 and R4 may be the same or different and are selected from the group consisting of C1-C10 alkyl, C1-C10 hydroxyalkyl, C1-C10 alkoxyalkyl, C1-C10 aryl, C1-C10 carboxylalkyl, C1-C10 alkyl sulfonate, mercapto alkyl and -(CH2)mN(R6)(R7); W1 and W2 may be the same or different and are selected from the group consisting of -S-, -O-, -Se-, -Te-, -NR8 and C(R9)(R10); and m is about 0-10; R8, R9, and R10 are independently hydrogen, C1-C10 alkyl, C1-C10 alkoxy, C1-C10 mercaptoalkyl, hydroxyl, C1-C10 hydroxyalkyl, C1-C10 alkoxyalkyl, C1-C10 aryl, C1-C10 carboxylalkyl, C1-C10 alkoxycarbonyl, C1-C10 alkylthio, and -(CH2)m-N(R6)(R7); and A is selected from the group consisting of -(CH2)-, -O-, -S-, or -NR8. Also provided are methods of using dyes of the invention comprising administering a diagnostically effective amount of the dye to a patient and visualizing the dye.