BIFENILSULFONILCIANAMIDAS PROCESSOS PARA A SUA PREPARACAO E SUA UTILIZACAO COMO MEDICAMENTOS

Biphenylsulphonylcyanamides of formula (I) and their salt are new: R1 = H, 1-8C alkyl, 1-naphthyl, 2-naphthyl, 3-7C cycloalkyl, (3-7C)cycloalkyl(1-2C)alkyl, or phenyl or phenyl(1-2C)alkyl optionally ring-substituted by 1-3 of 1-8C alkyl, halogen, CF3, SOnR11, OR17, NR8R9, CN, NO2 or COR22; R11 = 1-4...

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Hauptverfasser: SABINE FABER, JAN-ROBERT SCHWARK, HANS-WILLI JANSEN, ANDREAS WEICHERT, HANS JOCHEN LANG, HEINZ-WERNER KLEEMANN
Format: Patent
Sprache:por
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Zusammenfassung:Biphenylsulphonylcyanamides of formula (I) and their salt are new: R1 = H, 1-8C alkyl, 1-naphthyl, 2-naphthyl, 3-7C cycloalkyl, (3-7C)cycloalkyl(1-2C)alkyl, or phenyl or phenyl(1-2C)alkyl optionally ring-substituted by 1-3 of 1-8C alkyl, halogen, CF3, SOnR11, OR17, NR8R9, CN, NO2 or COR22; R11 = 1-4C alkyl or NR20R21; R20, R21 = H or 1-4C alkyl; R17 = H or 1-4C alkyl; R8, R9 = H or 1-4C alkyl; R22 = H, 1-8C alkyl or OR30; R30 = H or 1-8C alkyl; n = 0-2; or CR1R3 = 3-7C cycloalkylidene or fluorenylidene; R2-R5 = H, F, CF3, OR10, 1-8C alkyl, 3-7C cycloalkyl, or phenyl or phenyl(1-2C)alkyl optionally ring-substituted by 1-3 of halogen, CF3, Me, OMe, OH or NR18R19; R18, R19 = H or 1-4C alkyl; R10 = H, 1-8C alkyl, or phenyl or 1-9C heteroaryl optionally substituted by 1-3 of halogen, CF3, Me, OMe, OH or NR12R13; R12, R13 = H or 1-4C alkyl; or R2+R4 = a second bond; R6, R7 = H, halogen, CF3, CN, NO2, SOpR16, COR23 or OR24; R23 = H, 1-8C alkyl or OR25; R25 = H or 1-8C alkyl; R24 = H, 1-8C alkyl, or phenyl optionally substituted by 1-3 of halogen, CF3, Me, OMe, OH or NR28R29; R28 and R29 = H or 1-4C alkyl; R16 = 1-8C alkyl, or phenyl optionally substituted by 1-3 of halogen, CF3, Me, OMe, OH or NR26R27; R26, R27 = H or 1-4C alkyl; p = 0-2.