PROCESSO PARA A PREPARACAO DE ANALOGOS DA COLECISTOQUININA APROPRIADOS PARA O CONTROLO DO APETITE

The invention relates to peptides of the general formula X-(R)n-Tyr(SO3H)-(R )p-R -R -R -R -N-methyl-Phe-Y I wherein X = -CO-R , -CO-OR , -CO-(CH2)m-CH3, -CO-CO-OR , or -CO-(CH2)q-CO-OR Y = -OR or -NR R R = Asp, Aeg R = Met, Nle, Leu or Ile R = Gly, Ala, D-Ala, or beta -Ala R = Trp or Trp(For) R = Met, Nle or Nva R = Thr(SO3H), Ser(SO3H), or Hyp(SO3H) R = H or C1-3-alkyl, R = H, C1-3-alkyl, or halo-C1-3-alkyl R = H or C1-3-alkyl R = H or C1-3-alkyl R = H or C1-3-alkyl n = 0 or 1 p = O or 1 m = 3-14 q = 1-3 or 4-14 with the proviso that at least one of the variables X, R , p and q represent a residue which is emphasized and pharmaceutically acceptable salts thereof with food intake suppressing or appetite regulating activity. Such compounds can be prepared by treating the appropriate unsulfated peptides with a sulfating agent or treating the corresponding formylated peptides with a deformylating agent, and if desired, converting such a peptide obtained into pharmaceutically acceptable salts.