A METHOD FOR THE PRODUCTION OF CRYSTALLINE AMINO-PROTECTED-BETA-BENZYL-L-ASPARTIC ACID

A METHOD FOR THE PRODUCTION OF CRYSTALLINE AMINO-PROTECTED-BETA-BENZYL-L-ASPARTIC ACID

An amino-protected L-aspartic acid, such as t-butyloxycarbonyl-beta-benzyl-L-aspartic acid, is prepared by first forming the amino-protected compound in the presence of a tertiary amine base having a pKa value of about 9 to about 12, water, and a water-immiscible polar organic solvent so as to produ...

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Bibliographische Detailangaben
1. Verfasser: JOHN M. PASCONE
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:An amino-protected L-aspartic acid, such as t-butyloxycarbonyl-beta-benzyl-L-aspartic acid, is prepared by first forming the amino-protected compound in the presence of a tertiary amine base having a pKa value of about 9 to about 12, water, and a water-immiscible polar organic solvent so as to produce a non-aqueous solution containing a salt form of amino-blocked-beta-benzyl-L-aspartic acid. The thus produced non-aqueous solution is then isolated, or next acidified and treated further to ultimately recover therefrom the amino-protected L-aspartic acid in crystalline form.