PROCESSO DE PREPARACAO DE CONJUGADOS DE PROTEINAS

The immune response to the weakly-immunogenic hemagglutinin subunit protein antigen (HA) of influenza virus, type A or B, and other similar weakly-immunogenic viral protein antigens, is significantly increased by covalently linking the HA to a highly immunogenic protein, such as that of a bacterial...

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Bibliographische Detailangaben
Hauptverfasser: CYNTHIA S. BROWN, ROBERT D. LEMMON, COLEMAN R. HAMEL, PATRICK H. MCVERRY
Format: Patent
Sprache:por
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Zusammenfassung:The immune response to the weakly-immunogenic hemagglutinin subunit protein antigen (HA) of influenza virus, type A or B, and other similar weakly-immunogenic viral protein antigens, is significantly increased by covalently linking the HA to a highly immunogenic protein, such as that of a bacterial organism, for example, diphtheria toxoid and tetanus toxoid.