PROCESS FOR PREPARING PHOSPHINO-HYDROCARBON-GROUP VIII-METAL COMPLEXES USEFUL AS ANTITUMOR AGENTS

Novel bis[bis(diphenylphosphino)hydrocarbon] and bis[diphenylphosphino-diphenylarsino)hydrcarbon]-group VIII metal compounds of the formula 1 of the formula sheet, whereinD, = D2 = phosphorus or D, = phosphorus and D2 = arsenic;A = (CH2)2 or cis-CH = CH;X, = X2 (both if present) = halo or nitrato or...

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Hauptverfasser: KLAAS TIMMER, HARMEN ANNE MEINEMA
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creator KLAAS TIMMER
HARMEN ANNE MEINEMA
description Novel bis[bis(diphenylphosphino)hydrocarbon] and bis[diphenylphosphino-diphenylarsino)hydrcarbon]-group VIII metal compounds of the formula 1 of the formula sheet, whereinD, = D2 = phosphorus or D, = phosphorus and D2 = arsenic;A = (CH2)2 or cis-CH = CH;X, = X2 (both if present) = halo or nitrato or X, + X = peroxo;Y (if present) = halide, nitrate, perchlorate, triflate or tetrahaloferrate (III);n = 0, 1 or 2;M = Fe(II), Fe(III), Co(II), Rh(I), Rh(III), Ir(I), Ir(III), Ni(II) or Pd(II),showing a tumor cell growth-inhibiting activity, novel pharmaceutical compositions containing said compounds and a method for treating tumor cells, sensitive to said compounds.
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HARMEN ANNE MEINEMA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_PT83612A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1986</creationdate><topic>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</topic><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>KLAAS TIMMER</creatorcontrib><creatorcontrib>HARMEN ANNE MEINEMA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KLAAS TIMMER</au><au>HARMEN ANNE MEINEMA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PROCESS FOR PREPARING PHOSPHINO-HYDROCARBON-GROUP VIII-METAL COMPLEXES USEFUL AS ANTITUMOR AGENTS</title><date>1986-11-01</date><risdate>1986</risdate><abstract>Novel bis[bis(diphenylphosphino)hydrocarbon] and bis[diphenylphosphino-diphenylarsino)hydrcarbon]-group VIII metal compounds of the formula 1 of the formula sheet, whereinD, = D2 = phosphorus or D, = phosphorus and D2 = arsenic;A = (CH2)2 or cis-CH = CH;X, = X2 (both if present) = halo or nitrato or X, + X = peroxo;Y (if present) = halide, nitrate, perchlorate, triflate or tetrahaloferrate (III);n = 0, 1 or 2;M = Fe(II), Fe(III), Co(II), Rh(I), Rh(III), Ir(I), Ir(III), Ni(II) or Pd(II),showing a tumor cell growth-inhibiting activity, novel pharmaceutical compositions containing said compounds and a method for treating tumor cells, sensitive to said compounds.</abstract><edition>4</edition><oa>free_for_read</oa></addata></record>
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subjects ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title PROCESS FOR PREPARING PHOSPHINO-HYDROCARBON-GROUP VIII-METAL COMPLEXES USEFUL AS ANTITUMOR AGENTS
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