PROCESS FOR PREPARING PHOSPHINO-HYDROCARBON-GROUP VIII-METAL COMPLEXES USEFUL AS ANTITUMOR AGENTS

PROCESS FOR PREPARING PHOSPHINO-HYDROCARBON-GROUP VIII-METAL COMPLEXES USEFUL AS ANTITUMOR AGENTS

Novel bis[bis(diphenylphosphino)hydrocarbon] and bis[diphenylphosphino-diphenylarsino)hydrcarbon]-group VIII metal compounds of the formula 1 of the formula sheet, whereinD, = D2 = phosphorus or D, = phosphorus and D2 = arsenic;A = (CH2)2 or cis-CH = CH;X, = X2 (both if present) = halo or nitrato or...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: KLAAS TIMMER, HARMEN ANNE MEINEMA
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Novel bis[bis(diphenylphosphino)hydrocarbon] and bis[diphenylphosphino-diphenylarsino)hydrcarbon]-group VIII metal compounds of the formula 1 of the formula sheet, whereinD, = D2 = phosphorus or D, = phosphorus and D2 = arsenic;A = (CH2)2 or cis-CH = CH;X, = X2 (both if present) = halo or nitrato or X, + X = peroxo;Y (if present) = halide, nitrate, perchlorate, triflate or tetrahaloferrate (III);n = 0, 1 or 2;M = Fe(II), Fe(III), Co(II), Rh(I), Rh(III), Ir(I), Ir(III), Ni(II) or Pd(II),showing a tumor cell growth-inhibiting activity, novel pharmaceutical compositions containing said compounds and a method for treating tumor cells, sensitive to said compounds.