ESFINGOSSOMAS PARA UM FORNECIMENTO DE DROGAS MELHORADO

ESFINGOSSOMAS PARA UM FORNECIMENTO DE DROGAS MELHORADO

Liposomal formulations having extended circulation time in vivo and increased drug retention are comprised of sphingomyelin and cholesterol and have an acidic intraliposomal pH. The formulations have enhanced stability and thus are used in methods which provide improved drug delivery and more effect...

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Bibliographische Detailangaben
Hauptverfasser: LAWRENCE D. MAYER, MARCEL B. BALLY, JAMES M. MILLER, PAUL G. TARDI, MURRAY S. WEBB
Format: Patent
Sprache:por
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:Liposomal formulations having extended circulation time in vivo and increased drug retention are comprised of sphingomyelin and cholesterol and have an acidic intraliposomal pH. The formulations have enhanced stability and thus are used in methods which provide improved drug delivery and more effective treatment. The delivery of lipophilic drugs such as the vinca alkaloids, and particularly vincristine and vinblastine, to tumors is significantly improved.