COMPOSTOS PENTACICLICOS INTERMEDIARIOS PROCESSOS COMPOSICOES E METODOS

The present invention relates to compounds of formula I and II; wherein X is -O-, -S-, or -NR -; Y is -O-, -S-, -CH2-, -CH2CH2-, -CH=CH-, or -NR -; B is -CH - or -CO-; R , R , and R are each independently -H, -OH, -O(C1-C4 alkyl), -OCOC6H5, -OCO(C1-C6 alkyl), -OSO2(C4-C6 alkyl), -OSO2CF3, Cl, or F;...

Ausführliche Beschreibung

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Bibliographische Detailangaben
1. Verfasser:	TIMOTHY ALAN GRESE
Format:	Patent
Sprache:	por
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to compounds of formula I and II; wherein X is -O-, -S-, or -NR -; Y is -O-, -S-, -CH2-, -CH2CH2-, -CH=CH-, or -NR -; B is -CH - or -CO-; R , R , and R are each independently -H, -OH, -O(C1-C4 alkyl), -OCOC6H5, -OCO(C1-C6 alkyl), -OSO2(C4-C6 alkyl), -OSO2CF3, Cl, or F; n is 1 or 2; W is CH2 or C=O; R is 1-piperidinyl, 2-oxo-1-piperidinyl, 1-pyrrolidinyl, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidinyl, 2-oxo-1-pyrrolidinyl, 4-morpholino, dimethylamino, diethylamino, or 1-hexamethyleneimino; R is C1-C3 alkyl, -COC6H5, -CO(C1-C6 alkyl), -C(O)OC6H5, -C(O)O(C1-C6 alkyl), -SO2(C1-C6 alkyl), -SO2C6H5, or -SO2CF3; or a pharmaceutically acceptable salt thereof. Also provided by the present invention are intermediate compounds; processes for the preparation of compounds of Formulae I and II; and pharmaceutical methods and formulations employing the compounds of Formulae I and II.