PROCESSO E SAIS DIASTEREOMERICOS UTEIS PARA A RESOLUCAO OPTICA DE ALFA-¬4-(1,1-DIMETILETIL)-FENIL|-4-(HIDROXIDIFENILMETIL)-1-PIPERIDINOBUTANOL RACEMICO E COMPOSTOS DERIVADOS

PROCESSO E SAIS DIASTEREOMERICOS UTEIS PARA A RESOLUCAO OPTICA DE ALFA-¬4-(1,1-DIMETILETIL)-FENIL|-4-(HIDROXIDIFENILMETIL)-1-PIPERIDINOBUTANOL RACEMICO E COMPOSTOS DERIVADOS

A process and diastereomeric salts useful for the optical resolution of racemic alpha-[4-(1,1-dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1 -piperidinebutanol, 4-[4-[4-(hydroxydiphenylmethyl)-1 -piperidinyl]-1-hydroxybutyl]-alpha,alpha-dimethylbenzeneacetic acid and lower alkyl 4-[4-[4-(hydroxyd...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MASATOSHI SHIGA, MITSUO NAKAMURA
Format: Patent
Sprache:por
Schlagworte:
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:A process and diastereomeric salts useful for the optical resolution of racemic alpha-[4-(1,1-dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1 -piperidinebutanol, 4-[4-[4-(hydroxydiphenylmethyl)-1 -piperidinyl]-1-hydroxybutyl]-alpha,alpha-dimethylbenzeneacetic acid and lower alkyl 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-alpha,alpha-dimethylbenzeneacetates. The process comprises placing into solution a chiral resolving agent, either (+)/(-)-di-paratoluoyltartaric acid or (-)/(+)-mandelic acid, in an amount equimolar to a compound corresponding to the desired enantiomer of the above compound, precipitating the resulting diastereomeric salt between the chiral resolving agent and the target enantiomer and separating the enantiomer.