DERIVADOS DE SULFONIL- OU SULFINIL-BENZOIL-GUANIDINA

4-Sulphonyl- and 4-sulphinyl-benzoyl-guanidine derivs. of formula (I) and their salts are new: R = A, CF3, CH2F, CHF2, C2F5, CN, NO2 or halo; R = SOn-R , SO2NR R , NO2 or CF3; R = H, halo, A, OH, OA, CN, NO2, CF3, CH2F, CHF2, C2F5 or CH2CF3; R , R = H, A, 5-7C cycloalkyl, 4-8C cycloalkylmethyl, Ph o...

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Bibliographische Detailangaben
Hauptverfasser:	NORBERT BEIER, MANFRED BAUMGARTH, ROLF GERICKE, KLAUS-OTTO MINCK
Format:	Patent
Sprache:	por
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	4-Sulphonyl- and 4-sulphinyl-benzoyl-guanidine derivs. of formula (I) and their salts are new: R = A, CF3, CH2F, CHF2, C2F5, CN, NO2 or halo; R = SOn-R , SO2NR R , NO2 or CF3; R = H, halo, A, OH, OA, CN, NO2, CF3, CH2F, CHF2, C2F5 or CH2CF3; R , R = H, A, 5-7C cycloalkyl, 4-8C cycloalkylmethyl, Ph or benzyl; or R +R = 4-5C alkylene group where a CH2 may also be replaced by O, S, NH, NA or NCH2Ph; R = A, Ph, Het or 3-7C cycloalkyl; Het = mono- or dinuclear saturated, unsaturated or aromatic heterocycle contg. 1-4 N, O and/or S atoms, bound via N or C, and opt. up to three-fold substd. by halo, SH, SA, NH2, NHA, NA2, CF3, A, OH, OA, CN, NO2 and/or carboxylic acid; A = 1-6C alkyl; halo = F, Cl, Br or I; Ph = Ph (opt. up to three-fold substd. by A, OA, NR R , F, Cl, Br, I or CF3); n = 1 or 2.