NANOPARTICULAS MEDICAMENTOSAS MODIFICADAS A SUPERFICIE

Dispersible particles consisting essentially of a crystalline drug substance having a surface modifier adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than about 400 nm, methods for the preparation of such particles and dispersions conta...

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Bibliographische Detailangaben
Hauptverfasser: JOHN GORDON BISHOP, GARY LIVERSIDGE, KENNETH CUNDY, DAVID ALAN. CZEKAI
Format: Patent
Sprache:por
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Zusammenfassung:Dispersible particles consisting essentially of a crystalline drug substance having a surface modifier adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than about 400 nm, methods for the preparation of such particles and dispersions containing the particles. Pharmaceutical compositions containing the particles exhibit unexpected bioavailability and are useful in methods of treating mammals.