ANDROGEN RECEPTOR MODULATING COMPOUNDS

ANDROGEN RECEPTOR MODULATING COMPOUNDS

Compounds of formula (I) wherein R1 to R16, A. B and E are as defined in the claims and pharmaceutically acceptable salts and esters thereof, are disclosed. The compounds of formula (I) possess utility as tissue-selective androgen receptor modulators (SARM) and are particularly useful as medicaments...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: OLLI TÖRMÄKANGAS, IISA HÖGLUND, PATRIK HOLM, SIRPA RASKU, GERD WOHLFAHRT, ANNIINA VESALAINEN, ARJA KARJALAINEN, PIA KNUUTTILA, HARRI SALO
Format: Patent
Sprache:eng ; por
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:Compounds of formula (I) wherein R1 to R16, A. B and E are as defined in the claims and pharmaceutically acceptable salts and esters thereof, are disclosed. The compounds of formula (I) possess utility as tissue-selective androgen receptor modulators (SARM) and are particularly useful as medicaments in the treatment of prostate cancer and other AR dependent conditions and diseases where AR antagonism is desired.