SUBSTITUTED TETRAHYDROCARBAZOLE AND CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS
R1 is F, Cl, -CN, or -CH3; R2 is Cl or -CH3; R3 is -C(CH3)2OH or -CH2CH2OH; Ra is H or -CH3; each Rb is independently F, Cl, -CH3, and/or -OCH3; and n is zero, 1, or 2. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical composi...
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| creator | JOSEPH A. TINO GEORGE V. DELUCCA QINGJIE LIU MYRA BEAUDOIN BERTRAND QING SHI MICHAEL A. GALELLA ANURAG S. SRIVASTAVA DOUGLAS G. BATT SCOTT HUNTER WATTERSON SOO SUNG KO CHARLES M. LANGEVINE |
| description | R1 is F, Cl, -CN, or -CH3; R2 is Cl or -CH3; R3 is -C(CH3)2OH or -CH2CH2OH; Ra is H or -CH3; each Rb is independently F, Cl, -CH3, and/or -OCH3; and n is zero, 1, or 2. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease. |
| format | Patent |
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LANGEVINE</creator><creatorcontrib>JOSEPH A. TINO ; GEORGE V. DELUCCA ; QINGJIE LIU ; MYRA BEAUDOIN BERTRAND ; QING SHI ; MICHAEL A. GALELLA ; ANURAG S. SRIVASTAVA ; DOUGLAS G. BATT ; SCOTT HUNTER WATTERSON ; SOO SUNG KO ; CHARLES M. LANGEVINE</creatorcontrib><description>R1 is F, Cl, -CN, or -CH3; R2 is Cl or -CH3; R3 is -C(CH3)2OH or -CH2CH2OH; Ra is H or -CH3; each Rb is independently F, Cl, -CH3, and/or -OCH3; and n is zero, 1, or 2. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.</description><language>eng ; por</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170810&DB=EPODOC&CC=PT&NR=3013814T$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170810&DB=EPODOC&CC=PT&NR=3013814T$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>JOSEPH A. 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LANGEVINE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>SUBSTITUTED TETRAHYDROCARBAZOLE AND CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS</title><date>2017-08-10</date><risdate>2017</risdate><abstract>R1 is F, Cl, -CN, or -CH3; R2 is Cl or -CH3; R3 is -C(CH3)2OH or -CH2CH2OH; Ra is H or -CH3; each Rb is independently F, Cl, -CH3, and/or -OCH3; and n is zero, 1, or 2. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | SUBSTITUTED TETRAHYDROCARBAZOLE AND CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS |
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