SUBSTITUTED TETRAHYDROCARBAZOLE AND CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS

R1 is F, Cl, -CN, or -CH3; R2 is Cl or -CH3; R3 is -C(CH3)2OH or -CH2CH2OH; Ra is H or -CH3; each Rb is independently F, Cl, -CH3, and/or -OCH3; and n is zero, 1, or 2. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical composi...

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Bibliographische Detailangaben
Hauptverfasser:	JOSEPH A. TINO, GEORGE V. DELUCCA, QINGJIE LIU, MYRA BEAUDOIN BERTRAND, QING SHI, MICHAEL A. GALELLA, ANURAG S. SRIVASTAVA, DOUGLAS G. BATT, SCOTT HUNTER WATTERSON, SOO SUNG KO, CHARLES M. LANGEVINE
Format:	Patent
Sprache:	eng ; por
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	R1 is F, Cl, -CN, or -CH3; R2 is Cl or -CH3; R3 is -C(CH3)2OH or -CH2CH2OH; Ra is H or -CH3; each Rb is independently F, Cl, -CH3, and/or -OCH3; and n is zero, 1, or 2. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.