1-((3-((1-PIPERAZINYL)CARBONYL)PHENYL)METHYL)-2,4(1H,3H)-QUINAZOLINEDIONE DERIVATIVES AS PARP INHIBITORS FOR TREATING CANCER

Disclosed are 1-(arylmethyl)quinazoline-2,4(1H,3H)-diones represented by the Formula (I):wherein Ar, R1-R6 are defined herein. Compounds having Formula (I) are PARP inhibitors. Therefore, compounds of the invention may be used to treat clinical conditions that are responsive to the inhibition of PAR...

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Bibliographische Detailangaben
Hauptverfasser:	QINGBING XU, SISHUN KANG, CHENGYUN GU, QINGLI BAO, FENG YIN, LIJUN LIU, YANGZHEN JIANG, YE EDWARD TIAN, SUI XIONG CAI, SHENGZHI CHEN, GUOXIANG WANG, XIAOZHU WANG, HAIJUN DONG, XIUHUA HU, LIZHEN WU
Format:	Patent
Sprache:	eng ; por
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed are 1-(arylmethyl)quinazoline-2,4(1H,3H)-diones represented by the Formula (I):wherein Ar, R1-R6 are defined herein. Compounds having Formula (I) are PARP inhibitors. Therefore, compounds of the invention may be used to treat clinical conditions that are responsive to the inhibition of PARP activity.