METHODS AND REAGENTS FOR EFFICIENT AND TARGETED GENE TRANSFER TO CELLS OF MONOCYTE-MACROPHAGE LINEAGE

The present invention provides a biosafe and useful vector to transfer genetic material to CD 14+ mononuclear cells (monocytes and monocyte-derived macrophages) in an efficient and specific manner. The embodiment of the invention makes use of the chimeric human adenovirus vectors 5 carrying the shor...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	MIGUEL CHILLON RODRIGUEZ, ESTER FERNANDEZ GIMENO, ADOLFO RIO FERNANDEZ, MIQUEL ANGEL GASSULL DURO
Format:	Patent
Sprache:	eng ; por
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention provides a biosafe and useful vector to transfer genetic material to CD 14+ mononuclear cells (monocytes and monocyte-derived macrophages) in an efficient and specific manner. The embodiment of the invention makes use of the chimeric human adenovirus vectors 5 carrying the short fiber of enterotropic Ad40 to transfer genetic material to the target CD14+ mononuclear cells.