GLUCAGON RECEPTOR MODULATOR

GLUCAGON RECEPTOR MODULATOR

or a pharmaceutically acceptable salt thereof wherein R1, R2, R3, A1, A2, A3, A4, L, B1, B2, B3 and B4 are as defined herein. The compounds of Formula I have been found to act as glucagon antagonists or inverse agonists. Consequently, the compounds of Formula I and the pharmaceutical compositions th...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: ANGEL GUZMAN-PEREZ, BENJAMIN DAWSON STEVENS, MARY THERESA DIDIUK, ESTHER CHENG YIN LEE, JEFFREY ALLEN PFEFFERKORN, GARY ERIK ASPNES, KEVIN JAMES FILIPSKI, MEIHUA MIKE TU
Format: Patent
Sprache:eng ; por
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:or a pharmaceutically acceptable salt thereof wherein R1, R2, R3, A1, A2, A3, A4, L, B1, B2, B3 and B4 are as defined herein. The compounds of Formula I have been found to act as glucagon antagonists or inverse agonists. Consequently, the compounds of Formula I and the pharmaceutical compositions thereof are useful for the treatment of diseases, disorders, or conditions mediated by glucagon.