METHOD FOR PURIFYING THE RABIES VIRUS

The subject of the invention is a method for purifying the rabies virus, comprising a single ion-exchange chromatography step, said step being cation exchange chromatography according to which: a) the supernatant of a culture of cells infected with this virus is brought into contact with a cation ex...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: ERIC CALVOSA, CÉLINE ROCCA, VIRGINIE FABRE, PIERRE RIFFARD
Format: Patent
Sprache:eng ; por
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Beschreibung
Zusammenfassung:The subject of the invention is a method for purifying the rabies virus, comprising a single ion-exchange chromatography step, said step being cation exchange chromatography according to which: a) the supernatant of a culture of cells infected with this virus is brought into contact with a cation exchange chromatography support comprising a polymethacrylate matrix onto which sulfoisobutyl groups have been grafted such that the rabies virus binds to this support, and; b) the virus is eluted from its support.