PH-SENSITIVE LIPOSOME BINDING TO NUCLEOLIN

PH-SENSITIVE LIPOSOME BINDING TO NUCLEOLIN

The present invention provides a system presenting site-specific accumulation through a ligand that specifically targets a receptor overexpressed on the surface of specific cells within a target organ, like, for example, tumor cells and/or vascular cells of tumor blood vessels. Moreover, this invent...

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Bibliographische Detailangaben
Hauptverfasser: VERA LÚCIA DANTAS NUNES CALDEIRA DE MOURA, MARIA DA CONCEIÇÃO MONTEIRO PEDROSO DE LIMA, JOÃO NUNO SERENO DE ALMEIDA MOREIRA, SÉRGIO PAULO DE MAGALHÃES SIMÕES
Format: Patent
Sprache:eng ; por
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention provides a system presenting site-specific accumulation through a ligand that specifically targets a receptor overexpressed on the surface of specific cells within a target organ, like, for example, tumor cells and/or vascular cells of tumor blood vessels. Moreover, this invention provides a method where, upon internalization of the previous-mentioned system by the target cells, triggered release at a high rate of the associated agent takes place, permitting efficient intracellular delivery and, thus, increased concentration of the transported cargo at the target site. Overall, this invention provides a method for the diagnosis, prevention and treatment of human diseases and disorders.